Although PLSCR1 has several previously described anti-influenza functions, including interfering with viral nuclear import (Luo et al., 2018), regulating TLR9 signaling (Talukder et al., 2012), and potentiating the expression of other ISGs (Dong et al., 2004), our studies have clarified the relative contribution of the type 3 IFN pathway to Plscr1-mediated anti-influenza immunity using Plscr1-/-;Ifnlr1-/- mice. This evidence concerns the gene IFNLR1 and influenza.