We hypothesize that this disease progression could have been driven by the two separate mutations noted as variants of unclear significance in IKZF1 (variant allele frequencies/VAF 7.3% and 40.9%) given the known association between IKZF1 mutations and poor outcomes in B‐cell acute lymphoblastic leukemia [18]. Here, IKZF1 is linked to B-cell acute lymphoblastic leukemia.