GSTM1 and pneumonia: Acute pain requiring visit to a medical facility and admin of pain meds (opioids or IV NSAIDs) or RBC transfusionACS: new pulmonary infiltrate with pneumonia-like symptoms, pain, or feverSplenic sequestration: an enlarged spleen, LUQ pain, and an acute decrease in Hb of ≥2 g/dLPriapism lasting >2 h and requiring a visit to a medical facilitySevere VOE defined as above. Inpatient hospitalization for severe VOE was separate end point (hospitalization-free for ≥12 consecutive months HF12)