Serous tubal intraepithelial carcinomas have been identified as a precursor lesion to serous carcinoma and follow a predictable oncogenesis that stems from a near-universal driver TP53 mutation that is seen in 95 % of serous cancers (Kindelberger et al., 2007, Kuhn et al., 2012, Hanley et al., 2015). Opportunistic salpingectomy (OS) refers to the removal of the entire fallopian tube to reduce the risk of ovarian cancer during gynecologic surgery (Opportunistic salpingectomy as a strategy for epithelial ovarian cancer prevention. Here, TP53 is linked to ovarian carcinoma.