To evaluate the protein expression patterns of cultured MCC 14/2 cells, we performed immunofluorescence analysis using the epithelial cell marker cytokeratin (CK) 14.2 Further, we evaluated immunofluorescence of MC marker proteins CK8 and 20.28 The cultured cells were immunopositive for all markers localized on cell membrane and/or on cytoplasm (green in Figs. 1A–C), suggesting that they have the characteristics of MCs. This evidence concerns the gene KRT8 and Merkel cell skin cancer.