MAPK8 and Parkinson disease: Studies on PD model mice have found that the JNK inhibitor SP600125 can significantly reduce the expression levels of key proteins in the JNK/AP-1 signaling pathway, key proteins in the NLRP3 inflammasome, and inflammatory factors in microglia, indicating that the JNK/AP-1 signaling pathway plays a crucial driving role in the neuroinflammatory responses mediated by aging microglia.133