The PIAS2 signaling pathway in PD involves multiple type I interferons (IFNs), their receptors, and downstream molecules, including dysregulation of the IFNG, IFNGR1, and STAT4 genes, as well as up-regulation of negative regulators such as PIAS2, suggesting a blockade of the IFNβ-IFNAR signaling pathway.66 Here, PIAS2 is linked to Parkinson disease.