LRRC8A and epilepsy: In epilepsy investigations, while increased LRRC8A expression has been documented in perilesional astrocytes with potential implications for neuronal excitability via glutamate release, several questions remain unresolved: whether this up-regulation represents a causative factor or a consequential response to epileptogenesis; the precise glutamate threshold required for seizure initiation; and the cell type-specific functions of LRRC8A throughout the central nervous system.