CGAS and neoplasm: The STING signaling pathway is a critical component of cellular innate immune responses, capable of sensing cytosolic DNA and activating interferon production to counteract viral infections and tumor development.98, 99, 100, 101 cGAMP, a signaling molecule synthesized by cyclic GMP-AMP synthase (cGAS) upon recognition of cytoplasmic DNA, is crucially translocated across the cell membrane by LRRC8A/VRAC.90