Mechanistically, Yu et al (2021) uncovered that TBX4 modulated the expression of E74-like ETS transcription factor 4 (ELF4), RUNX family transcription factor 3 (RUNX3), and zinc finger MIZ-type containing 1 (ZMIZ1) in B cells of systemic lupus erythematosus patients, contributing to systemic lupus erythematosus immunopathology.124. This evidence concerns the gene RUNX3 and systemic lupus erythematosus.