SEPTIN9 and colorectal carcinoma: The first test is for a molecular biomarker, methylated SEPT9. This qualitative PCR assay to detect methylated Septin9 DNA shed by CRC cells into the bloodstream was approved in 2016 [28]. The test is called Epi proColon 2.0 and is approved to be used to screen adults 50 years or older at average risk for CRC.