Since most individuals at risk for CRC choose FIT against colonoscopy as the first CRCS test of choice, this study is an important evidential step assessing these three CRCS alternatives, although not a randomized study with 10,369 patients, 1900 of whom had FIT < 10 μg Hb/g feces. The gene discussed is GSTM1; the disease is colorectal carcinoma.