We identified several hub genes (including KIF20A, CAV1, OTX1, CMTM5, MYBL2, SCN2B, CTNNA3, PLP1, CRYAB, DES, FHL1, NRG1, HJURP, TPX2, etc.) within the PPI network, which strongly suggests that they may play critical roles in cancer-related biological networks. This evidence concerns the gene DES and cancer.