For example, among chemokines and their receptors, upregulated hub genes showed positive correlations with several members of the CCL and CXCL families (e.g., CCL1, CCL4, CCL5, CCL20, CXCL1, CXCL5, CXCL8–11), particularly in BRCA, LUAD, and COAD. The gene discussed is CCL4; the disease is colon adenocarcinoma.