For example, among chemokines and their receptors, upregulated hub genes showed positive correlations with several members of the CCL and CXCL families (e.g., CCL1, CCL4, CCL5, CCL20, CXCL1, CXCL5, CXCL8–11), particularly in BRCA, LUAD, and COAD. Here, CXCL8 is linked to colon adenocarcinoma.