A strong dichotomy emerged: many genes were consistently downregulated in both primary and metastatic tumors such as CAV1, CRYAB, FHL1, DES, MYL9, NRG1, SORBS1, SYNM, TCEAL2, MYBL2 (except in lung↑), MASP1 (except colon/lung↑), FOLR1 (except colon↑), ABCG2 (except colon/lung↑), and PYGM (except colon/lung↑) suggesting they may act as cancer-suppressive genes. The gene discussed is DES; the disease is cancer.