We identified several hub genes (including KIF20A, CAV1, OTX1, CMTM5, MYBL2, SCN2B, CTNNA3, PLP1, CRYAB, DES, FHL1, NRG1, HJURP, TPX2, etc.) within the PPI network, which strongly suggests that they may play critical roles in cancer-related biological networks. The gene discussed is PLP1; the disease is cancer.