Furthermore, multivariate Cox regression analysis showed that DDX49 expression (high vs. low) was an independent prognostic factor (HR = 2.351, 95% CI: 1.333-4.147; P = 0.003; Table 3), indicating that DDX49 expression had a statistically significant independent association with survival outcomes in CRC patients. The gene discussed is DDX49; the disease is colorectal carcinoma.