CD4 and cancer: Validation through multiple deconvolution algorithms—including Tumor Immune Estimation Resource (TIMER), Microenvironment Cell Populations-counter (MCPCOUNTER), xCELL, Estimation of Proportions of Immune and Cancer cells (EPIC), and Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT)—confirmed CD58’s robust association with CD8+ T cell and CD4+ T cell infiltration in GBM (Figures 3C, D).