CD58 was significantly upregulated in most tumors (Figure 1A), with notable overexpression in breast invasive carcinoma (BRCA), cervical squamous cell carcinoma (CESC), cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), glioblastoma (GBM), head and neck squamous cell carcinoma (HNSC), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and liver hepatocellular carcinoma (LIHC) compared to adjacent normal tissues (p < 0.05). This evidence concerns the gene CD58 and cervical squamous cell carcinoma.