AKT1 and neoplasm: Regulated by HIF-α, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), TWIST1, snail family transcriptional repressor 2 (Slug), phosphatidylinositol 3-kinase (PI3K), AKT, and PKA (364, 365, 367), vasculogenic mimicry generates mosaic vessels that facilitate the shedding of tumor cells into the circulation, thereby promoting metastasis (368).