Regulated by HIF-α, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), TWIST1, snail family transcriptional repressor 2 (Slug), phosphatidylinositol 3-kinase (PI3K), AKT, and PKA (364, 365, 367), vasculogenic mimicry generates mosaic vessels that facilitate the shedding of tumor cells into the circulation, thereby promoting metastasis (368). The gene discussed is SNAI2; the disease is neoplasm.