Aberrant activation of JAK-STAT signaling, often driven by genetic mutations (supplementary tables) that occur upstream or within core components of the pathway, plays a pivotal role in the pathogenesis of various hematologic malignancies, including myeloproliferative neoplasms, acute leukemias, and mature lymphoid neoplasms (160). This evidence concerns the gene SOAT1 and myeloproliferative neoplasm.