GPT and Pruritus: Nonetheless, the addition of ICIs treatment is associated with increases risks of fever (RR = 1.59, 95% CI 1.05-2.43), hypothyroidism (RR = 3.28, 95% CI 2.34-4.58), hyperthyroidism (RR = 3.87, 95% CI 2.27-6.62), rash (RR = 2.23, 95% CI 1.60-3.11), pruritus (RR = 2.46, 95% CI 1.68-3.60), and increased serum alanine aminotransferase (RR = 2.20, 95% CI 1.35-3.57).