Mechanistically, Yang et al. (2023) demonstrated that macrophage STING deletion decreases TBK1–LAST1-mediated inhibitory phosphorylation of YAP, thereby enhancing nuclear YAP activity to promote lipid metabolism, fatty acid oxidation, and lipophagy-dependent degradation of the lipid droplet protein PLIN2, collectively alleviating steatosis and oxidative stress (63). This evidence concerns the gene STING1 and steatosis.