The ROC curves for PI3K/AKT/mTOR-related DEGs showed that the expression of MMP3 (AUC = 0.969; Fig. 8f) and IL24 (AUC = 0.919; Fig. 8g) had high accuracy in discriminating the two different subtypes or risk groups of cSCC in the GEO dataset, followed by KRT75 (AUC = 0.698; Fig. 8h), AKT1 (AUC = 0.644; Fig. 8i), and AKT3 (AUC = 0.642; Fig. 8j). Here, AKT1 is linked to skin squamous cell carcinoma.