81. NR2F1 is the main regulator and activator of tumor cell dormancy 82. NR2F1 induces cell dormancy via SOX9 and NANOG. Additionally, SOX9 upregulates the expression of p16 and p27 83. NANOG, a transcription factor 84, upregulates the transcription of p21 and p27, thereby promoting cell dormancy 85. This evidence concerns the gene CDKN1B and neoplasm.