The proteases rich in NETs can degrade laminin-111 in the extracellular matrix, exposing specific epitopes, which are then recognized by the integrin α3β1 on the surface of dormant cancer cells, thereby activating downstream signaling pathways such as FAK/ERK/MLCK/YAP, prompting cancer cells to transition from dormancy to proliferation. The gene discussed is PTK2; the disease is cancer.