EGFR and Meckel syndrome, type 1: 1 RTK I glioblastomas show increased amplification of platelet derived growth factor receptor A (PDGFRA), while RTK II glioblastomas are enriched with amplification of epidermal growth factor receptor (EGFR) gene, and MES glioblastomas show no typical recurring alterations. 6-8 Clinically, patients with RTK II glioblastomas show a significantly higher incidence of seizures compared to those suffering from tumors of RTK I and MES subtypes. 9