CDKN2A and melanoma: 10CDKN2A encodes the p16 and p14 proteins. 10 Inactivation of the gene group CDKN2A/B is a phenomenon that can be found in various malignancies, such as melanoma, 10 and non-small lung cancer. 38, 39 Common mechanisms of inactivation include somatic mutations, promoter methylation and chromosomal losses. 10, 22, 40