Co-expressed genes such as ROCK1 (Rho-associated coiled-coil kinase 1), RAC1 (Ras-related C3 botulinum toxin substrate 1), ACTN4 (alpha-actinin-4), and ARP2/3 (actin-related protein 2/3) complex members are involved in actin polymerization, lamellipodium extension, and focal adhesion dynamics, hallmarks of invasive and mesenchymal-like glioma phenotypes. This evidence concerns the gene ACTN4 and glioma.