Furthermore, GMI treatment led to an increase in i-NOS mRNA levels in M1 macrophages and a decrease in CD206 mRNA levels in M2 macrophages, confirming that GMI enhanced pro-inflammatory and anti-tumour M1 macrophages while reducing the anti-inflammatory and pro-tumour M2 macrophages (Fig. 6B). This evidence concerns the gene MRC1 and neoplasm.