Building on prior findings that the plant-derived omega-3 fatty acid stearidonic acid (SDA) inhibits NF-κB in prostate cancer 25, we examined whether SDA could synergize with cisplatin to overcome chemoresistance in cisplatin-resistant SKOV3 and OVCAR-5 ovarian cancer cells. The gene discussed is NFKB1; the disease is ovarian carcinoma.