The transmembrane glycoproteins cluster of differentiation 133 (CD133), aldehyde dehydrogenase 1 (ALDH1), and leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) are CSC markers in CRC 7, 8 and other various cancers 9-11. The gene discussed is LGR5; the disease is colorectal carcinoma.