Contrary, Bi Y. et al. 2020 reported that M1 macrophages may inhibit angiogenesis and tumor growth by promoting the production of CXCL9, CXCL10, and CXCL11 in CRC, and that their predominance may serve as a marker of favorable prognosis in CRC 173. The gene discussed is CXCL11; the disease is colorectal carcinoma.