Wang et al., 2023 have recently demonstrated that markers of M1 macrophages (NOS2, CXCL10, CD11c) were weakly expressed in both the invasive front and tumor center (TC), whereas M2 markers (CD163, CD206, CD115) were primarily expressed in the invasive front in primary CRC. The gene discussed is CXCL10; the disease is colorectal carcinoma.