Based on specific gene signatures and functions, the following types of TAMs have been distinguished: interferon-primed tumor-associated macrophages (IFN-TAMs), immune regulatory tumor-associated macrophages (Reg-TAMs), inflammatory cytokine enriched tumor associated macrophages (Inflam-TAMs), lipid-associated tumor-associated macrophages (LA-TAMs), pro-angiogenic tumor-associated macrophages (Angio-TAMs), RTM-like tumor-associated macrophages (resident-tissue macrophages (RTM-TAMs), glycolytic TAMs (Table 1) 42, 44. The gene discussed is IFNA1; the disease is neoplasm.