Interestingly, a reanalysis of interleukin-1β blockade in sepsis demonstrated benefits for patients with elevated ferritin levels.[35] Oh et al. reported that mAb 7F IgG, a novel IL-1β-specific antibody, effectively blocks the IL-1β pathway and exhibits anti-colitis activity in IBD mouse models.[36] Additionally, the IL-1R antagonist anakinra has been evaluated in clinical trials for IBD to assess its impact on macroscopic and histological changes, inflammatory cell infiltration, and oxidative stress in colitis.[37]. Here, IL1R1 is linked to colitis.