CD274 and colorectal cancer: For instance, colorectal cancer-derived hsa-miR-21-5p and hsa-miR-200a synergistically induce macrophage M2-like polarisation and upregulate programmed cell death-ligand 1 (PD-L1) expression, thereby suppressing CD8+ T-cell activity and promoting tumour growth.[8] Besides, exosomal miRNAs offer superior clinical utility.