APOE and Alzheimer disease: Furthermore, certain genotypes have been linked to the association between falls and dementia, with older adults who carry the apolipoprotein E (APOE) ε4 allele having an increased risk of dementia after falls.[7,10] The onset of AD involves numerous pathogenic and risk genes, and the mechanisms are complex.[11,12] Nevertheless, the role of genetic susceptibility in the association between falls and dementia risk is largely unknown.