The autophagy receptor SQSTM1/p62 facilitates degradation of the iron export protein ferroportin 1 (FPN1) in lysosomes, leading to the accumulation of intracellular iron ions, which promotes ferroptosis.[95] Moreover, RAB7A-mediated lipophagy enhances lipid peroxidation in iron-deficient anemia.[97] The inhibition of SLC7A11 mediated by BECN1 results in GSH depletion and subsequent ferroptosis. The gene discussed is SQSTM1; the disease is anemia.