This mechanism subsequently triggers ferroptosis in cancer cells.[164] Similarly, radiotherapy activates ataxia telangiectasia mutated protein (ATM) to suppress the expression of SLC7A11, thereby enhancing ferroptosis sensitivity.[186] Another case is that IFN-γ activates interferon receptor (IFNR)/JAK/STAT1 signaling pathway, causing the transcriptional factor interferon regulatory factor 1(IRF1) to transactivate ACSL4 expression in tumor cells. The gene discussed is IRF1; the disease is neoplasm.