HMGB1 and neoplasm: Importantly, ferroptosis is also considered a form of immunogenic cell death, as evidenced by the release of immune regulatory molecules known as damage-associated molecular patterns (DAMPs), such as oxidized high mobility group box 1 (HMGB1), decorin, and TLR2.[226,227] Additionally, immune cell-derived cytokines such as IFN-γ modulate the ferroptosis signaling in tumor cells, thereby affecting their sensitivity to ferroptosis.