Nonetheless, the tight temporal relationship to methimazole initiation, high-titer antinuclear antibody (ANA) with anti-histone antibodies and hypocomplementemia, absence of anti-dsDNA/ENA, lack of renal or neurologic involvement, and sustained remission after withdrawal favored DILE over hypersensitivity or idiopathic SLE. Here, BTG3 is linked to systemic lupus erythematosus.