HDAC9 and neoplasm: Specifically, we propose a spatially targeted combinatorial strategy that integrates: (i) local microbial restoration via precision delivery of Streptococcus and Acetivibrio consortia to tumor-adjacent niches (e.g., through hydrogel-based spatial delivery systems) and (ii) metabolic modulation with butyrate analogs or HDAC inhibitors, tailored to regions with confirmed butyrate depletion and HDAC dysregulation.