SENP1 and neoplasm: Consistent with the bioluminescence results in Fig. 6B, SENP1-silenced groups (GFP-shSENP1 and HBx-shSENP1) exhibited either markedly smaller liver tumors or no visible tumor formation, demonstrating that SENP1 silencing substantially impaired tumor outgrowth in vivo (Figs. 6D and S3).