In HBV-related HCC, elevated SENP1 (7.8 vs. 15.7 months, p = 0.003), OCT4 (7.8 vs. 16.7 months, p <0.001), SNAIL (8.6 vs. 15.7 months, p = 0.012), and TWIST (8.2 vs. 15.5 months, p = 0.028) were linked to early recurrence. Here, SENP1 is linked to hepatocellular carcinoma.