Multivariable linear regression analysis identified serum ALT (β coefficient: 0.12, 95% CI: 0.04–0.20, p = 0.006) and the histological degree of hepatic steatosis (β coefficient: 0.35, 95% CI: 0.12–0.59, p = 0.004) as the primary independent factors associated with elevated nuclear SHP localization. The gene discussed is GPT; the disease is fatty liver disease.