(2022) proposed that Klotho-derived short peptide fragments can specifically inhibit the Wnt/β-catenin signaling pathway (24).In diabetic kidney injury, the continuous activation of the Wnt/β-catenin pathway is considered to be an important driving force for glomerular sclerosis, abnormal proliferation of mesangial cells, and fibrosis. The gene discussed is KL; the disease is glomerulosclerosis.