KL and type 2 diabetes mellitus: (2024) found that the polymorphism of Klotho gene is closely related to metabolic phenotype (such as BMI, blood glucose level) and renal function parameters (such as eGFR) in Mexican patients with T2DM, suggesting that the genetic effect of Klotho not only affects the risk of diabetes, but also may change the disease process by regulating metabolism and renal function (77).