Furthermore, genetic research reveals somatic mutations in aldosterone-producing adenomas, including: KCNJ5 potassium channel mutations in 43-73% of cases, CACNA1D calcium channel mutations in 9-21%, ATP1A1 sodium/potassium ATPase mutations in 5-8%, and ATP2B3 plasma membrane calcium ATPase mutations in 1-3%. This evidence concerns the gene KCNJ5 and adenoma.