Non-metabolic GI sensing via K2P/SGLT; Fos/mRNA upregulation in hypoglycemia; OX1R → sympathetic increase in EGP; Gαi/o-cAMP-PKA → VTA glutamate/dopamine; AMPK/T-type Ca2+ channel in restriction. This evidence concerns the gene HCRTR1 and Hypoglycemia.