PHB2, expressed in the nucleus, mitochondria, and cytoplasm, has been noted to play crucial roles in models of various kidney injuries, such as diabetic nephropathy (Liu et al., 2022), angiotensin II-induced kidney injury (Xu et al., 2019), and ischemia–reperfusion injury (Wang et al., 2020). This evidence concerns the gene AGT and urogenital neoplasm.