Thus, a mosaic KRAS c.436G > A, (A146T) mutation, identified in three patients with SFMS (28, 42), has also been described in a number of patients with other similar syndromes, such as oculoectodermal syndrome (OES, OMIM #600268) and encephalocraniocutaneous lipomatosis (ECCL, OMIM #613001), which are characterized by a range of interconnected anomalies such as scalp lesions, epilepsy, epibulbar dermoid, cloudy cornea, eyelid coloboma, aorta coarctation, and variations in skin pigmentation. This evidence concerns the gene KRAS and encephalocraniocutaneous lipomatosis.