Thus, a mosaic KRAS c.436G > A, (A146T) mutation, identified in three patients with SFMS (28, 42), has also been described in a number of patients with other similar syndromes, such as oculoectodermal syndrome (OES, OMIM #600268) and encephalocraniocutaneous lipomatosis (ECCL, OMIM #613001), which are characterized by a range of interconnected anomalies such as scalp lesions, epilepsy, epibulbar dermoid, cloudy cornea, eyelid coloboma, aorta coarctation, and variations in skin pigmentation. Here, KRAS is linked to coloboma of eyelid.