SREBF1 and fatty liver disease: However, LXRα also activates sterol regulatory element-binding protein-1c (SREBP-1c), which induces the expression of lipogenic genes, including fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), and stearoyl-CoA desaturase 1 (SCD1), promoting hepatic fatty acid synthesis and contributing to triglyceride accumulation and hepatic steatosis.44