NR1H4 and Pruritus: FXR agonists highlight a dual narrative: (1) pruritus is a class and on-target feature777,792 and (2) bile acids can induce itch via TGR5 on sensory neurons and activate TRPA1, suggesting a potential off-target/network amplifier for bile-acid-like or FXR/TGR5-active chemotypes.793