MPL and leukemia: In addition, we observed downregulation of leukemia-associated proto-oncogenes such as CCND1/2 (0.46, p < 0.05), CCNE2 (0.38 p = 0.0076), MYC (0.42, p < 0.001), SRC (0.3, p < 10−5), or MPL (0.25, p < 0.05) (Figures 3C, S4A, and S4B).