Interestingly, siRNA targeting of UCHL3 downregulated MCL1 and sensitized C4-2 and LNCaP95 PCa cells to navitoclax, AZD4320, and A-1331852, with induction of the intrinsic apoptosis pathway as evidenced by caspase 3/7 activation and PARP cleavage (Figures 5D, 5E, S7B, S7C, S8A, and S8B). Here, CASP3 is linked to posterior cortical atrophy.