Considering this finding, we next determined whether the UCHL3 siRNA, that induced downregulation of MCL1, sensitized C4-2 and LNCaP95 PCa cells to BH3 mimetics targeting BCL2/BCLXL (navitoclax and AZD4320) or BCLXL alone (A-1331852) (Figures 5D, 5E, S7B, S7C, S8A, and S8B). Here, UCHL3 is linked to posterior cortical atrophy.