Interestingly, when looking at the skin microbiota composition in infants with AD and FA, far more skin microbiota-related changes are found in patients with IgE CMA than in non-IgE CMA compared to HC (Figures 3C and S1C); regardless of whether it is the skin microbiome of cheek or that of the popliteal fossa (Tables 4 and S1). The gene discussed is IGHE; the disease is Alzheimer disease.