RFX3 and type 2 diabetes mellitus: ,37,38 Moreover, miRNA targets that were part of this cluster and are known to be associated with insulin secretion include RFX3,39CLOCK,40CACNA1D,41 and KCNB1. 42Both compensatory increase and dysfunctional decrease of glucose-stimulated insulin secretion are likely scenarios for how miRNAs regulate β-cell function in human T2D pathogenesis.12