ALPK3 and cardiomyopathy: Wei-Feng et al. demonstrated that ALPK3 double allele deletion can trigger lethal cardiomyopathy in an animal model study, approximately 75% of germline knockout mice die within one month of birth, and survivors exhibit a transformation from dilated cardiomyopathy to HCM, which is highly consistent with the clinical manifestations of compound heterozygous mutations in humans.