In animal models, ALPK3 knockout mice exhibit a mixed phenotype of hypertrophic and dilated cardiomyopathy, suggesting that ALPK3 plays a critical role in the development and function of cardiomyocytes (23), these findings imply that ALPK3 gene mutations may cause structural and functional abnormalities in cardiomyocytes and subsequently lead to cardiomyopathy. This evidence concerns the gene ALPK3 and cardiomyopathy.