ALPK3 and dilated cardiomyopathy: In animal models, ALPK3 knockout mice exhibit a mixed phenotype of hypertrophic and dilated cardiomyopathy, suggesting that ALPK3 plays a critical role in the development and function of cardiomyocytes (23), these findings imply that ALPK3 gene mutations may cause structural and functional abnormalities in cardiomyocytes and subsequently lead to cardiomyopathy.