These pathway preferences dictate cellular fate decisions: in the tumour microenvironment, mechanical signalling dominated by the Piezo1-YAP axis primarily drives gene programs associated with proliferation and migration [34,87], while co-activation of the TRPC6-NF-κB axis amplifies inflammatory responses and remodels the immune microenvironment atop the existing signals [88,89]. This evidence concerns the gene PIEZO1 and neoplasm.