In tumour mechanobiology, the function of Piezo1 cannot be understood in isolation; rather, it operates within a complex network of mechanosensitive ion channels, including TRP channels, two-pore potassium (K2P) channels (such as TREK-1 encoded by the KCNK2 gene), and the OSCA/TMEM63 family, among others [79]. The gene discussed is PIEZO1; the disease is neoplasm.