Beyond the broad characterization of inflammatory phenotypes, severalwell-defined signaling cascades have been implicated in both BD and IBD,suggesting convergent molecular mechanisms: nuclear Factorkappa-light-chain-enhancer of activated B cells pathway (NF-κB pathway),Janus kinase (JAK)–signal transducer and activator of transcription (STAT)cascade (JAK–STAT pathway), and NLRP3 inflammasome (NOD-, LRR-, and pyrindomain-containing protein 3 inflammasome). The gene discussed is NLRP3; the disease is inflammatory bowel disease.