Therefore, this pre-specified subgroup analysis evaluated the efficacy and safety of esaxerenone vs trichlormethiazide in hypertensive patients with T2DM, stratified by their baseline antihypertensive agent (ARB or CCB) and urinary albumin-to-creatinine ratio (UACR) (<30 mg/gCr or ≥30 mg/gCr). The gene discussed is ALB; the disease is type 2 diabetes mellitus.