Lipocalin-2 (LCN2), a member of the lipocalin protein family and an acute-phase protein, is predominantly produced by astrocytes during brain injury.16 In the context of BM, neutrophils also contribute to LCN2 production.17 LCN2 signals through several receptors, including SLC22A17 (also known as 24p3R or NGALR),17 LRP1,18 LRP2,19 and MC4R,20 with SLC22A17 garnering particular attention in cancer research.17,21 In models of ischemic stroke, LCN2 is markedly upregulated and enhances astrocytic phagocytic activity via LRP1, promoting neural repair. Here, LCN2 is linked to ischemic stroke.