Consistently, elevated CCL2 levels were detected in supernatants from LCN2-high tumor cells cocultured with astrocytes (Supplementary Fig. 8g) but not in supernatants from tumor cells alone (Supplementary Fig. 8i) or from those cocultured with oligodendrocytes (Supplementary Fig. 8j). The gene discussed is LCN2; the disease is neoplasm.