STAT3 and familial pancreatic carcinoma: A previous study reported a direct interaction between SLC22A17 and JAK2 in pancreatic cancer cells.27 We found that astrocytes cocultured with LCN2-high tumor cells presented increased phosphorylation of JAK2 and STAT3, whereas no significant changes in JAK1, JAK3, or STAT1 levels were detected (Supplementary Fig. 9a, b).