A previous study reported a direct interaction between SLC22A17 and JAK2 in pancreatic cancer cells.27 We found that astrocytes cocultured with LCN2-high tumor cells presented increased phosphorylation of JAK2 and STAT3, whereas no significant changes in JAK1, JAK3, or STAT1 levels were detected (Supplementary Fig. 9a, b). Here, LCN2 is linked to neoplasm.