Additionally, high RCAN1-4 expression was noted in adult gliomas with malignant molecular characteristics (Supplementary Fig. 2C) and was associated with the induction of specific mutations in GBM organoids, such as CDKN2A/B codeletion and EGFRvIII (Supplementary Fig. 2D). The gene discussed is CDKN2A; the disease is glioblastoma.