SPRY1 and neoplasm: We noted that T cells with high reactivity toward RCAN1-4 presented significantly greater expression of many tumor-reactive T cell-related genes, most notably CCL20 [65], SDC4 [71], and SPRY1 [64], with greater than twofold greater expression than T cells with low/no response to RCAN1-4 (Supplementary Fig. 11H).