In contrast, anti-MSLN uCAR-like NK cells actively penetrated the tumor spheroid, demonstrating significantly stronger penetration ability, which was 5.3 times greater than that of CIML NK cells, 5.8 times greater than that of anti-non CAR-like NK cells, and 3.2 times greater than that of anti-MSLN CAR-like NK cells (Fig. 6c). Here, MSLN is linked to neoplasm.