TRAF6 achieves this by catalyzing the K63-linked polyUb of mTOR, which functions within the p62-TRAF6 heterodimer complex.266 This mechanism not only activates mTORC1 but also modulates autophagy and cancer cell proliferation, underscoring the multifaceted role of TRAF6 in cellular homeostasis and oncogenesis. Here, TRAF6 is linked to cancer.