This intricate diversity in Ub chain types highlights the complexity and adaptability of ubiquitin-dependent mechanisms in regulating NF-κB signaling pathways.168 A20 serves as a negative regulator by removing K63-linked and linear Ub chains from target proteins, such as IKKγ and RIPK1.170 Patients with haploinsufficiency of A20 (HA20) have been identified in cases of familial autoinflammatory syndromes with Behçet-like features.171 This condition is discussed in detail in the “Autoinflammatory disorders” section. This evidence concerns the gene TNFAIP3 and autoinflammatory syndrome.