Siah-1 is crucial for the destabilization of YAP initiated by FRK.333 SKP2 mediates the K63-linked polyUb of YAP, enhancing its nuclear trafficking and transcriptional activity in cancer cells.334 TRIM11 stabilizes YAP by inducing its monoubiquitination.335 In contrast, SHARPIN promotes YAP degradation via K48-dependent polyUb.336. Here, YAP1 is linked to cancer.