YAP1 and pancreatic adenocarcinoma: Furthermore, USP49, a novel DUB of YAP1, promotes gastric cancer cell proliferation, metastasis, and chemoresistance.348 USP10 inhibits YAP1 ubiquitination, promoting Cyr61 expression and immune escape in pancreatic adenocarcinoma.349 EIF3H dissociates PUCs from YAP through a catalytic triad (Asp90, Asp91, and Gln121), stabilizing YAP and promoting tumor invasion and metastasis.350 USP9X deubiquitinates and stabilizes YAP1, supporting cancer cell survival.351